ACE and Alzheimer disease: Of the 35 newly identified associated genes, four genes (FAM241A at 4q25, SAPCD1 at 6p21.33, FAM 111A at 11q12.1, and ACE at 17q23.3) are more than 500 kb away from any GWAS-identified AD risk variants (Table 1 and Additional file 3: Table S3).