Of the remaining six genes, three (INPP5D at 2q37.1, MS4A2 at 11q12.1, and MS4A4E at 11q12.2) were suggested in previous GWAS for AD risk [7] and three genes (SLC24A4 at 14q32.12, CTSH at 15q25.1, and SETD1A at 16p11.2) were reported to be associated with AD risk in previous studies [35–37]. The gene discussed is MS4A2; the disease is Alzheimer disease.