Of the 35 AD-associated genes identified in analyses of brain tissues that have not been reported in previous TWAS, four of them, FAM241A at 4q25, SAPCD1 at 6p21.33, FAM 111A at 11q12.1, and ACE at 17q23.3, are located at novel loci (Table 1). The gene discussed is ACE; the disease is Alzheimer disease.