APOE and Alzheimer disease: Using graph theory formalism, previous studies found evidence of the ApoE4-related modulation on healthy aging, MCI, and the AD co-variance brain network based on physiological variables derived from different image modalities (rsFMRI, FDG-PET, and DWI) (Brown et al., 2011, Giau et al., 2015, Goryawala et al., 2015, Li et al., 2019, Sanabria-Diaz et al., 2021, Seo et al., 2013, Wang et al., 2015, Yao et al., 2015, Zhu et al., 2018).