This was achieved by injection of either WT or Tap1−/− bone marrow into irradiated MUP-core mice, followed by CLL treatment to deplete the residual radio-resistant KCs and allow the complete reconstitution of the entire KC compartment with bone marrow-derived cells (Sitia et al., 2011) (Figure 2S). This evidence concerns the gene TAP1 and B-cell chronic lymphocytic leukemia.