CALCA and B-cell chronic lymphocytic leukemia: This was achieved by (1) injecting Cdh5creERT2; Rosa26iDTR bone marrow into irradiated MUP-core mice, (2) depleting the residual radio-resistant KCs by CLL to allow the complete reconstitution of the entire KC compartment with bone marrow-derived cells, (3) inducing DTR expression in KC2 by tamoxifen administration, and finally (4) depleting KC2 by DT injection prior to Cor93 TN transfer followed by IL-2c treatment (Figure 5E).