This would also be consistent with studies that demonstrate mechanistic overlap between LTD and Aβo-induced synaptic decline in AD (Hsieh et al., 2006), and with the dependence of both processes on extrasynaptic NMDARs (Li et al., 2009; Papouin et al., 2012; Talantova et al., 2013). This evidence concerns the gene ABO and Alzheimer disease.