CD40LG and infection: Having analyzed 54 studies that used different antibody detection platforms, both commercial and in-house methods, the overall results showed a time-dependent increase in the sensitivity of antibody-based tests during active symptomatic infection, ranging from less than 30.1% in the first week for the pooled results of IgG, IgM, IgA total antibodies and IgG/IgM, to a pooled sensitivity of 91.4% (95% CI 87.0 to 94.4) during the third week of infection (days 15 to 21) for the combination of IgM/IgG.