Variant rs1537373 (Fig 1F; p-value 6.68 x 10−7, MAF 49.9%, OR 0.821) in CDKN2B-AS1, encoding the long non-coding RNA known as cyclin dependent kinase inhibitor CDKN2B antisense RNA1, is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21, a major genetic susceptibility locus for coronary artery disease, atherosclerosis and myocardial infarction [19]. Here, CDKN2B is linked to myocardial infarction.