In addition, we identified a linkage group of high-frequency variants (MAFs 9.56–9.97%, odds ratios 1.615–1.644) that do not reach the standard threshold for genome-wide significance for association with TAA, but fall in within FBN1, which encodes the fibrillin-1 protein FBN1 encodes the fibrillin-1 protein and is implicated in the pathogenesis of Marfan syndrome [29] (Table 4). The gene discussed is FBN1; the disease is Marfan syndrome.