Although, WSS cases with congenital immunodeficiency had been previously reported, and their main manifestations were recurrent infections of respiratory tract or urinary tract, and significantly reduced immunoglobulin level (IgG, IgA, and IgM) in peripheral blood (Bogaert et al., 2017; Stellacci et al., 2016), patient 2 had normal immunoglobulin and complement levels which were described in detail above. Here, CD40LG is linked to infection.