To gain a deeper understanding of SARS-CoV-2 host-virus interactions, a follow-up of 55 COVID-19 patients from April 2020 was performed encompassing (i) SARS-CoV-2 WGS and (ii) serological testing for anti-S/N IgG and IgM as well as IgG to S1, S2 and N. Of 55 COVID-19 patients with PCR-confirmed SARS-CoV-2 infection and viral WGS analysis, 49 patients reported back to the laboratory for antibody testing (Fig. 1). The gene discussed is CD40LG; the disease is COVID-19.