As a follow-up in the present study, we investigated anti-inflammatory and pro-resolving potential of MR-39 ex vivo (i.e., in organotypic hippocampal cultures obtained from WT and KO FPR2 mice stimulated with Aβ1-42) and in vivo in double transgenic amyloid precursor protein/presenilin1 (APP/PS1) mice, a well-accepted model of AD. This evidence concerns the gene PSEN1 and Alzheimer disease.