Hippocampal organotypic cultures (OHCs) have significant advantages over the use of primary cell cultures or cell lines because they maintain intact hippocampal architecture and functional interactions between brain cells and the neuroimmune and endocrine systems, which allows to assess the effect of the tested compounds on both neuronal and glial cells [34, 39, 40] Considering that FPR2 is expressed on microglial cells [27, 41, 42] astrocytes and hippocampal neurons [43], OHC represents a valid ex vivo model to study the role of this receptor in the inflammatory processes related to AD. This evidence concerns the gene FPR2 and Alzheimer disease.