In literature, most of studied TLR4 SNPs in Egyptian population were rs4986790 and rs4986791. Furthermore, they were studied in different disorders like pulmonary tuberculosis [26], colorectal cancer [27], familial Mediterranean fever [28], rheumatoid arthritis, and systemic lupus erythematosus [29]. Here, TLR4 is linked to systemic lupus erythematosus.