Although the exact pathogenic mechanism underlying natriuresis in CRSW syndrome is unclear, in some cases, it could be caused by the release of vasodilator mediators, such as atrial natriuretic peptide (ANP), brain natriuretic peptides (BNPs), and C-type natriuretic peptide (CNP), that can promote diuresis, natriuresis, and hyponatremia. Here, NPPA is linked to Hyponatremia.