Therapy with a sodium-glucose cotransporter 2 inhibitor was specifically associated with an increased risk of DKA (IRR, 1.47; 95% CI, 1.27-1.70) but with a decreased risk of HHS (IRR, 0.65; 95% CI, 0.46-0.93) (eTable 7 in the Supplement). This evidence concerns the gene SLC5A2 and hypotrichosis 1.