Lopinavir and ritonavir (protease inhibitors, PIs, with the commercial name of Kaletra) induce the ER stress and oxidative pathway, which impair autophagy activity in melanoma and adipocyte cells, mTOR activity and protein expression enhanced in the skeletal muscle cells under PIs treatment, but the results obtain in vivo demonstrate the reduction of mTOR activity in mice [90–92]. This evidence concerns the gene MTOR and melanoma.