Heritability enrichment of age-related traits among gene regulators is consistent with the epigenetic dysregulation (Han and Brunet, 2012) and elevated transcriptional noise (López-Otín et al., 2013; Bahar et al., 2006) observed in aging (e.g. SIRT6 modulation influences mouse longevity and metabolic syndrome; Kanfi et al., 2012; Kanfi et al., 2010). The gene discussed is SIRT6; the disease is metabolic syndrome.