However, Sun et al. (2018) reported that alcohol treatment could increase NQO1 protein expression in hepatoblastoma cells, long‐term ethanol treatment increased NQO1 activity in mice, the results also showed that ethanol‐induced oxidative stress activated the expression of NQO1 in hepatocytes (Renon et al., 2016; Yeligar et al., 2010). Here, NQO1 is linked to hepatoblastoma.