CD4 and colitis: Comparison of human and mouse T cells, using the Helicobacter hepaticus anti-IL10R model of colitis,35 suggested similarities in αE+CD8+ T cells (Figures 5H, S3D, and S3G), whereas the proinflammatory state of αE+CD4+ human T cells is directly opposite that of murine αE+CD4+ T cells, which have a regulatory T cell phenotype and produce significantly less inflammatory cytokines (Figures S3E and S3F).