IDH1 and neoplasm: In a retrospective cohort study of 486 patients IDHwt tumours were significantly more likely to undergo MT than IDHmut/codel tumours (P < .001). The 5-year estimates of freedom from MT were 82% for IDHwt and 92% for IDHmut/codel tumours.37In 131 patients, lack of IDH1 mutation was independently and significantly associated with shortened MFS (P = .019).38In 74 patients, MFS was significantly shorter in IDHwt tumors (39.0, 25.6–52.4 months) than in IDHmut tumours (64.6, 57.3–71.9 months) (P = .003).45