Of note, the VDE was significantly slower in tumors with 1p19q codeletion (P =.008) and with complete 1p deletion (P = .042) and was significantly faster in tumors with p53 overexpression (P = .003).20 Another study of 168 patients demonstrated that VDE ≥ 4 mm/y, VDE ≥ 8 mm/y, and VDE ≥ 12 mm/y all statistically conferred significantly shorter MFS compared to tumours with VDE < 4 mm/y (P < .001 for all 3 thresholds). Here, TP53 is linked to neoplasm.