TP53 and neoplasm: Positive TP53 mutation status (but not P53 overexpression) was the lone risk factor with respect to MT in a series with 159 patients.50In 36 patients, TP53 was strongly associated with MT. Nine of 14 tumors (75%) harboring TP53 mutations showed MT within 12 ± 75 months (median 37 months), compared to 9/22 tumors (41%) wild type TP53 tumours.51