C3 and diabetes mellitus: Furthermore, in a study of more than 400 patients with NAFLD, it was shown that PRO-C3, as a single marker or as a composite marker within the ADAPT score (age, diabetes, platelets, and PRO-C3), was superior to APRI (AST to platelet ratio index), FIB-4, and NAFLD Fibrosis score for identification of advanced liver fibrosis.23