CTSB and cardiovascular disorder: In addition, we identified a major complement of lysosomal cathepsins in our proteomic data that have been previously linked with cardiovascular diseases, including cathepsins B, C, D, and Z (Guo et al., 2002; Moheimani et al., 2012; Wolinsky et al., 1978; Letronne et al., 2016; Wu et al., 2017; Thottath et al., 2019; Campden and Zhang, 2019).