The co-delivery system displayed a highly efficient synergistic effect (Fig. 7b): on the one hand, Pt induced apoptosis and simultaneously produced H2O2, together with the irons (Fe2+/Fe3+) released from IONP significantly increased the ROS generation (remarkably •OH) via the Fenton reaction within GBM cells; while on the other hand, si-GPX4 can effectively know down the negative regulator (GPX4) acted on the ferroptotic process. This evidence concerns the gene GPX4 and glioblastoma.