TGFB1 and cancer: TGFβ1 is considered as a multifunctional cytokine since TGF-β1 has been reported as a master inducer of EMT in both physiological such as fetal development, regulation of cell proliferation and differentiation, scar formation and fibrosis induction and pathological situations such as angiogenesis migratory phenotype and cancer progression (EMT type 3) [17].