Also, there is a negative correlation between adiponectin and kisspeptin signaling pathway so that increased level of adiponectin results in a significant decrease of kisspeptin synthesis [26] or decreased adiponectin levels is associated to increased levels of kisspeptin synthesis in polycystic ovary syndrome and following increased LH/FSH ratio [30]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.