Reducing expression of antiapoptotic regulators such as cIAP 1, Bcl-2, catalase,clusterin, HO-1, livin, XIAP, HSP27 and claspin was also demonstrated in human breast cancer line [12]; the latter in support of mithochondrial apoptotic pathway using bromelain-based CHCT. The gene discussed is CLSPN; the disease is breast carcinoma.