To the best of our knowledge, this is among the most comprehensive studies evaluating serum biochemical indexes and their relationship with LBP and among the first studies to compare serum levels of Fe, Cu, phosphorus, Al, and total protein aside to inflammatory markers (IL-6, IL-1B, CRP, and TNF-alpha) between those with and without LBP and in relation with degree of perceived pain. The gene discussed is IL1B; the disease is Low back pain.