ACHE and rheumatoid arthritis: Moreover, this treatment decreased ROS levels, lipid peroxidation, and reduced AChE enzyme activity accompanied by reduced degenerated cells in the hippocampus of NBM lesioned rats [19]. Since E. amoenum is a potential source of flavonoids and RA, it seems that these constituents can protect the brain from diseases attributed to the oxidative damage, namely AD, through scavenging free radicals [6, 22].