Recent studies demonstrated high levels of mTOR and FoxO1 expression in skin biopsies taken from acne patients concomitant with increased IGF-1 serum level [54, 55].Also, there is direct evidence for deviated FoxO1/mTORC1 signaling in the induction of acne vulagarissebofollicularinflammasomopathy [56], which is a key player in the initiation of oxidative mediated pathways. The gene discussed is IGF1; the disease is acne.