The diagnosis is probable if the patient presents a clinical syndrome involving sarcoidosis, with other examinations supporting the diagnosis, such as MRI or laboratory tests suggest a CNS inflammation (elevated levels of CSF proteins or cells, presence of oligoclonal bands) as well as positive systemic sarcoidosis (either positive histology or at least two indirect indicators from Gallium scan, chest imaging, and serum ACE), with no evidence of alternative disease. The gene discussed is ACE; the disease is sarcoidosis.