However, our experiments do not rule out other possibilities as potential mechanisms.42–45 Third, confirmative experimental evidence that mechanical force directly affects SARS2 infection in a setting of authentic SARS2 and live cells is still absent, although we demonstrate that SARS2 exploits mechanical force to impede spike/ACE2 dissociation and accelerate subsequent S1/S2 detachment for effective pseudovirus infection. This evidence concerns the gene ACE2 and infection.