Interestingly, we observed a significant association between genotypes of rs8176719 at the ABO locus and the serum level of IL-1β (Spearman’s correlation rs = −0.274, P = 2.61 × 10−15, Fig. 2a), despite no association between IL-1β and COVID-19 severity in our samples (Table 3 and Fig. 2b). The gene discussed is ABO; the disease is COVID-19.