The association between rs8176719 and IL-1β remains significant after dichotomizing IL-1β as normal (≤12 pg/ml) and abnormal (> 12 pg/ml) and controlling for COVID-19 severity, age, and sex (OR = 0.22 [0.10–0.50], P = 2.28 × 10−4, Wald test based on logistic regression, Fig. 2b–d). Here, IL1B is linked to COVID-19.