Importantly, USP15 was recently reported to have additional relevant functions in hematopoietic and chronic myelogenous leukemia models, including the regulation of the DNA damage response and in the suppression of p53 via deubiquitination of MDM2 [26, 32, 48]. The gene discussed is MDM2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.