In contrast, combined knockdown of USP15 and NRF2 significantly impaired the cell viability and leukemic progenitor function of the AML cells (shNRF2;shUSP15-OCI-AML3 vs shSCR;shUSP15-OCI-AML3) (Figs. 5I, J and S3F). The gene discussed is RUNX2; the disease is acute myeloid leukemia.