RUNX2 and acute myeloid leukemia: Restoration of KEAP1 expression in shUSP15-OCI-AML3 cells resulted in a partial rescue of leukemic progenitor function as compared to control shUSP15-OCI-AML3 cells (Fig. 5H), suggesting that functional defect of AML cells upon loss of USP15 is in part mediated by the disrupted stoichiometry of KEAP1 in the redox response.