Consistent with prior findings showing that P53 loss increased penetrance and accelerated progression of leukemia [28, 32], we showed here that PHF6 loss increased JAK3M511I-induced T-ALL initiation by downregulating BAI1 expression, thereby decreasing BAI1 and MDM2 interaction, and destabilizing P53 (modeled in Fig. 8). This evidence concerns the gene TP53 and acute lymphoblastic leukemia.