The VC Phf6 + JAK3M511I mice showed more aggressive leukemia phenotypes than Phf6 WT + JAK3M511I mice, including higher white blood cells (WBCs), neutrophils (Neu), and lymphocytes (Lym) in PB (Figs. 2D, E and S1F). The gene discussed is PHF6; the disease is leukemia.