IGF2 and Large for gestational age: A possible mechanism by which GWG patterns are associated with the risk of LBW or macrosomia is epigenetic modifications in nonimprinted genes induced by aspects of the developmental environment [42]; during the 1944–1945 famine in the Netherlands, the periconceptional exposure to famine was associated with lower methylation of the differentially methylated regions (DMRs) in insulin-like growth factor 2 (IGF2) gene.