To better understand the direct impact of NPs on adipose tissues in vivo and to determine their functional significance, we investigated whether or not exogenous ANP treatment induces WAT “browning”, and promotes BAT activation, as well as whether it attenuates hepatic steatosis, in diet-induced obese mice, resulting in the amelioration of systemic insulin resistance. The gene discussed is NPPA; the disease is Hepatic steatosis.