To explore phytosterolemia induced changes in gene expression, we next examined the gene expression profiles from 21 cardiac tissue samples that were collected from ABCG5/8 DKO and ABCG5/8, NPC1L1 TKO mice three weeks after the simultaneous placement on a phytosterol-enriched diet and initiation of either ezetimibe (10 mg/kg, QD) or vehicle control treatment. Here, NPC1L1 is linked to sitosterolemia.