Our study focused on the assessment of an association between polymorphisms rs1047972, rs2273535, rs8173 and rs911160 (AURKA), rs2289590 and rs2241909 (AURKB), rs11084490 and rs758099 (AURKC) and rs42873 (PLK1), and a risk of glioblastoma multiforme (GBM) development in the population of Bosnia and Herzegovina. The gene discussed is PLK1; the disease is glioblastoma.