We examined the expression of miR-19a in ER+ and ER− cancer cell lines and found that the ER+ bone-tropic breast cancer cells, MCF7BoM2 and T47DBoM, have a higher endogenous expression of miR-19a compared to the parental cell lines, MCF7 and T47D (Fig. 1d). Here, ESR1 is linked to breast cancer.