TP53 and neoplasm: CAL-51 cell lines showed significant differences in tumor growth by TP53 genotype, with TP53 null cell lines having significantly increased tumor growth compared to TP53 WT, R175H, or R273H mutant cells (WT vs Null, P = 0.035; R175H vs Null, P = 0.008; R273H vs Null, P = 0.022; Fig. 5b).