Uterine carcinosarcoma (UCS), uterine corpus endometrial carcinoma (UCEC), lung squamous cell carcinoma (LUSC), ovarian (OV), and breast cancers (BRCA) with missense TP53 mutations displayed the highest median FGA across all cancer types (Fig. 7a). This evidence concerns the gene TP53 and uterine carcinosarcoma.