In the combined dataset, the PPV of the combined tests (43.24%), using the top quintile of CRS as a cutoff and positivity for VCA-/EBNA1-IgA, was 9-fold greater than the PPV using EBV serology alone (4.70%), with a subtle decrease in the NPV (99.91%) (Table 3). This evidence concerns the gene CD79A and congenital rubella syndrome.