Here, we observed that rs2071430 and rs17000900 in the promoter of myxovirus resistance 1 (MX1), a key effector of interferon23, also show significant associations with the COVID-19 severity (P = 3.8 × 10−6 and P = 0.0050, respectively, in the main analysis; Supplementary Table S13). Here, MX1 is linked to COVID-19.