Neurotoxic Aβ oligomers can interact with and activate NMDA receptor90,91 and affect NMDA receptor signaling.90,92,93 Overactivation of NMDA receptors causes excitotoxicity and neuronal cell damage,94 whereas chronic NMDA receptor hyperactivity contributes to neuron loss in the development of AD.95 The Food and Drug Administration-approved drugs for treating AD, such as rivastigmine, galantamine, donepezil, memantine, memantine-donepezil combination, and tacrine, block glutamate NMDAR, inhibit acetylcholinesterase, or have a combination of both effects. The gene discussed is ACHE; the disease is Alzheimer disease.