A group of genes associated with late-onset AD implicated in lipid metabolism (APOE [apolipoprotein E]),42,43 immune response (APOE, AGT [angiotensinogen]),41 and the lysosome pathway (CTSF [cathepsin F], LAMP1 [lysosomal associated membrane protein 1])44 were involved in this network. This evidence concerns the gene APOE and Alzheimer disease.