ACAA1 and Alzheimer disease: The DEGs between ACAA1 p.N299S and ACAA1 WT were significantly enriched (P < 0.05, Fisher’s exact test) in a co-expression network (Padjust < 0.0001) (Fig. 2c) that was found to be abnormally regulated in brain tissues of AD patients,41 in which ACAA1 was located in a central position of the network.