In this study, we detected the expression level of HIF-1α and Beclin1 in 80 pairs of OSCC tissues and adjacent normal tissue, and our results suggested that HIF-1α and Beclin1 were both highly expressed in OSCC tissues compared with normal tissues and were significantly associated with large tumor size, advanced TNM grade, high pathological grade and lymphocytic infiltration. The gene discussed is HIF1A; the disease is neoplasm.