We also observed that the genes corresponding to the SNPs used for the PRS calculation in this study were involved in diverse pathogenesis of AD, such as cholesterol metabolism (APOE, CLU, ABCA7), tau toxicity (BIN1, CD2AP, FERMT2, CASS4, PTK2B), immune response (CR1, CD33, MS4A, TREM2), and endocytosis (BIN1, PICALM, CD2AP, SPHA1, SORL1) [3, 50]. This evidence concerns the gene TREM2 and Alzheimer disease.