MAPT and Alzheimer disease: We also observed that the genes corresponding to the SNPs used for the PRS calculation in this study were involved in diverse pathogenesis of AD, such as cholesterol metabolism (APOE, CLU, ABCA7), tau toxicity (BIN1, CD2AP, FERMT2, CASS4, PTK2B), immune response (CR1, CD33, MS4A, TREM2), and endocytosis (BIN1, PICALM, CD2AP, SPHA1, SORL1) [3, 50].