We also observed that the genes corresponding to the SNPs used for the PRS calculation in this study were involved in diverse pathogenesis of AD, such as cholesterol metabolism (APOE, CLU, ABCA7), tau toxicity (BIN1, CD2AP, FERMT2, CASS4, PTK2B), immune response (CR1, CD33, MS4A, TREM2), and endocytosis (BIN1, PICALM, CD2AP, SPHA1, SORL1) [3, 50]. The gene discussed is CR1; the disease is Alzheimer disease.