The alteration frequency in BC subtypes was summarized in Fig. 7A. As shown in Fig. 7B, the alteration percentage of these four genes varied from 2.7 to 8% (SRD5A3, 5%; DOLK, 8%; SRD5A1, 6%; HSD17B3, 2.75), and the alterations included missense mutation, splice mutation, truncating mutation, amplification, and deep deletion. The gene discussed is SRD5A3; the disease is breast cancer.