CTNNB1 and colorectal carcinoma: Wu et al. have shown that the polyubiquitination and degradation of TRAF6 induces the accumulation of CTNNB1, which contributes to aberrant activation of Wnt/β-catenin signaling and thereby promotes the epithelial-mesenchymal transition and metastasis (EMT) of colorectal cancer (CRC )[52].