Given that CIRP is a known RNA-binding protein, and its main role in the cytoplasm is to bind specific mRNAs (IRES-containing mRNAs) to facilitate their translation upon stress [7], we wondered whether the cytoplasmic CIRP of NSCLC cells would also promote the IRES-dependent translation of CTNNB1. Here, PTBP1 is linked to non-small cell lung carcinoma.