Mechanistically, CIRP directly bound to the 3′- and 5′-UTRs of CTNNB1 mRNA to enhance its stability and translation, and the resultant accumulation of CTNNB1 protein induced excessive activation of Wnt/β-catenin signaling and promoted the progression of NSCLC. The gene discussed is CTNNB1; the disease is non-small cell lung carcinoma.