Further studies revealed that circRNF13 directly binds and stabilizes SUMO2 mRNA, which upregulates the protein levels of SUMO2 and promotes GLUT1 degradation by means of SUMOylation and ubiquitination, thus inhibiting the glycolytic process and proliferation, migration, and invasion of NPC. The gene discussed is SUMO2; the disease is nasopharyngeal carcinoma.