SOD1 and liver dysplastic nodule: The results showed that lipoic acid combined with valsartan for the treatment of DN was much more effective in increasing the level of SOD than valsartan or lipoic acid monotherapy(P = 0.03, SMD = 1.24, 95%CI = 0.32 to 1.03; P = 0.0002, SMD = 0.68, 95%CI = 0.32 to 1.03).