TWIST1 and lung adenocarcinoma: In lung adenocarcinoma, UTX and its COMPASS family member, MLL4, were statistically increased in brain metastasis compared to primary tumor; they also induced the expression of several EMT-transcription factors (TFs), such as ZEB1, Slug and Twist, indicating that UTX may regulate the expression of EMT-TFs epigenetically and affect distant metastasis [25].