Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX)—also known as KDM6A—is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27); it is involved in embryonic development, tissue-specific differentiation, and cancer growth [11, 12]. The gene discussed is KDM6A; the disease is cancer.