2011; Dallmeier et al. 2012). Elevated circulating levels of hsCRP and IL-6 predict the development of T2DM through diminishing insulin sensitivity (Guarner & Rubio-Ruiz 2015). Obesity-induced inflammation has been implicated as a risk factor in the pathogenesis of T2DM, insulin resistance, CVD, and metabolic syndrome (Kumar et al. 2019). This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.