Blockade of LFA-1 and VLA-4 in the coculture infection model (Fig. 4A) resulted in 65.4%–96.2% (median 85.2%) inhibition of HIVIIIB and 78.1%–96.9% (median 93.4%) inhibition of HIVBaL infection of rCD4s cocultured with TNFα-treated HUVECs (p = .0002 and p = .0017, respectively, Fig. 5B). The gene discussed is TNF; the disease is infection.