Utilizing Syk- or CARD9-deficient bone marrow chimeric mice (referred to as Syk−/− or CARD9−/− chimeras and the respective wild-type controls as WtSyk and WtCARD9 chimeras), we also provide evidence that this pathway confers protection in the setting of invasive C. parapsilosis infection, which becomes especially apparent in the late phase of the infection. Here, SYK is linked to infection.